Scientific Programme
Bradykinin Symposium

Thursday, 15 September 2022

12:00-12:45

Lunch

12:45-13:00

Welcome
Marcus Maurer, Markus Magerl (Germany)

Session I: Bradykinin Basics

13:00-13:50

Kinin Formation, turnover and signaling
Thomas Renné (Germany)

13:50-14:15

The kallikrein-kinin system and its neighbors
Michael Bader (Germany)

14:15-14:45

Coffee Break 

Session II: News in Bradykinin biology

14:45-15:10

The role of arachidonic acid metabolites for bradykinin-induced dermal extravasation. Studies in mice and humans.
Georg Kojda (Germany)

15:10-15:35

Hereditary Angioedema with a Mutation in the Plasminogen
Allen Kaplan (USA)

The pathophysiology of BK in COVID
Allen Kaplan (USA)

15:35-16:00

The endothelial response to Bradykinin and other vasoactive substances
Maria Bova (Italy)

16:00-16:30

Coffee Break

Session III: Short oral presentations

16:30-16:40

Characteristics of pediatric subjects with C1-HAE deficiency in the ITACA cohort
Riccardo Senter (Italy)

16:40-16:50

A novel pathogenetic factor of laryngeal attack in hereditary angioedema? Involvement of Protease Activated Receptor 1
László Cervenak (Hungary)

16:50-17:00

Bradykinin receptor-1 on monocytes and granulocytes increase rapidly after LPS
Erik Nielsen (Norway)

17:00-17:10

Development of Dutch National Dynamic Flowchart and Registry for Angioedema
Marloes W. Heijstek (Netherlands)

17:10-17:20

Comorbidities in Angioedema due to C1-inhibitor deficiency: an Italian survey
Riccardo Senter (Italy)

17:20-17:25

Closing Remarks

17:25-18:10

Walk to Dinner Location

18:10-18:45

Reception

20:15-20:45

Quiz

20:45-23:00

Scientific Dinner

Friday, 16 September 2022

8:00-8:15

Coffee and Welcome

8:15-8:20

Summary day 1
Marcus Maurer, Markus Magerl (Germany)

Session IV: Bradykinin and angioedema

8:20-8:35

Classification of angioedema: The 2022 approach
Avner Reshef (Israel)

8:35-8:50

How to measure Bradykinin and other kinins in angioedema patients
Björn Burckhardt (USA)

8:50-9:05

Clinical and Laboratory evaluation of Bradykinin mediated angioedema
Henriette Farkas (Hungary)

9:05-9:20

Genetics and its use for diagnostics in angioedema
Anastasios Germenis (Greece)

9:20-9:35

AAE: The neglected little brother
Anete S Grumach (Brazil)

9:35-10:05

Coffee Break

Session V: Short Oral Presentations

10:05-10:15

Pharmacology of KVD824, an Investigational Drug for Prophylaxis of HAE
Vesna Grivcheva-Panovska (Macedonia)

10:15-10:25

Pharmacological characterization of a novel oral FXIIa inhibitor KV998086
Allen Clermont (USA)

10:25-10:35

Pregnancy in women with Hereditary Angioedema due to C1-inhibitor deficiency: Results from the ITACA cohort study on outcome of mothers and children with in utero exposure to plasma-derived C1-inhibitor
Paola Triggianese (Italy)

10:35-10:45

Sebetralstat, Investigational Oral On-Demand Treatment for HAE: KONFIDENT Trial Design
Emel Aygören-Pürsün (Germany)

10:45-10:55

Development of PHA121 for On-Demand and Prophylactic Treatment of HAE
Giorgio Giannattasio (Switzerland)

10:55-11:05

In vivo CRISPR/Cas9 editing of KLKB1 in Patients with HAE
Hilary Longhurst (New Zealand)

11:05-11:25

Coffee Break

Session VI: Hereditary angioedema

11:25-11:40

Comorbidities in HAE
Linda Sundler Björkman (Sweden)

11:40-11:55

Mortality in HAE
Fernanda Minafra (Brazil)

11:55-12:10

On demand treatment from the patients’ perspective in real life
Semra Demir (Turkey)

12:10-12:25

Outcome measures of acute therapy for hereditary angioedema
Lauré Fijen (Netherlands)

12:25-12:45

Modern prophylaxis in real life
Laurence Bouillet (France)

12:45-13:35

Lunch

Session VII: Hereditary angioedema

13:35-13:55

Update on HAE with normal C1-INH: Mutations and clinical features
Konrad Bork (Germany)

13:55-14:15

Bradykinin formation in HAE with normal C1-INH
Allen Kaplan (USA)

14:15-14:45

Pathomechanism in HAE with normal C1-INH beyond Bradykinin – Round table discussion
Konrad Bork (Germany), Thomas Renne (Germany),
Allen Kaplan (USA)

14:45-15:25

Poster Session

Session VIII: HAE worldwide

15:25-15:45

HAE in India: A country with 30000 patients?
Ankur Jindal (India)

15:45-16:05

Prophylaxis as standard treatment? What can we learn from Canada?
Stephen Betschel (Canada)

16:05-16:25

All for the patient: HAEi & ACARE
Henrik Boysen (Denmark)

16:25-16:45

Speculating about future treatments
Danny Cohn (Netherlands)

16:45-17:00

Conclusions: What did we hear? What take we home?
Markus Magerl (Germany)

17:00-17:15

Closing remarks
Marcus Maurer, Markus Magerl (Germany)

as of 13 September 2022

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